12-oxo Leukotriene B4
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产品名称:
12-oxo Leukotriene B4
产品型号:
GOY-Y0125
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-07
简单介绍
12-oxo Leukotriene B4DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,PBS (pH 7.2): > 1 mg/ml
12-oxo Leukotriene B4
的详细介绍
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性能参数
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产品名称
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12-oxo Leukotriene B4
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规格
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10μg 25μg 50μg 100μg
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货号
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GOY-Y0125
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含量
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>90.00%
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CAS
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136696-10-1
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别名
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N/A
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化学名
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N/A
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分子式
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C20H30O4
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分子量
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分子 334.4
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溶解度
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DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,PBS (pH 7.2): > 1 mg/ml
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储存条件
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Store at -20°C
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General tips
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General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
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用途
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仅供科研
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价格
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电询
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详细内容
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Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.
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