性能参数

产品名称

14,15-Leukotriene E4

规格

25μg 50μg 100μg

货号

GOY-Y0138

 含量

>97.00%

CAS

1000852-57-2

别名

N/A

化学名

N/A

分子式

C23H37NO5S

分子量

分子 439.6

溶解度

DMF: > 50mg/ml,DMSO: > 50mg/ml,Ethanol: > 50mg/ml,PBS (pH 7.2): > 100μ g/ml

储存条件

Store at -20°C

General tips

General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

用途

仅供科研

价格

电询

详细内容

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils. Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.

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