性能参数

产品名称

20-HETE

规格

25μg 50μg 100μg 500μg

货号

GOY-Y0217

 含量

>98.00%

CAS

79551-86-3

别名

N/A

化学名

N/A

分子式

C20H32O3

分子量

分子 320.47

溶解度

0.1 M Na2CO3: 2 mg/ml ;DMF: Miscible ;DMSO: Miscible;Ethanol: Miscible;PBS pH 7.2: 0.8 mg/ml

储存条件

Store at -20°C

General tips

General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

用途

仅供科研

价格

电询

详细内容

20-HETE(20-hydroxy Arachidonic Acid) is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells. It depolarizes VSM by blocking the open-state probability of Ca2+-activated K+-channels.IC50 Value:Target: 20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450-derived arachidonic acid metabolite that has been shown to increase smooth muscle contractions and proliferation, stimulate endothelial dysfunction and activation and promote hypertension. in vitro: Addition of 20-HETE to the bath (1-100 nM), reduced the frequency of opening of the large-conductance Ca(2+)-activated K+ channel recorded using cell-attached patches on VSM [1]. In kidney, 20-HETE induces diuresis by inhibiting Na+-K+-ATPase in proximal tubules and Na+/K+/Cl+ cotransporter in the thick ascending limb of Henle’s loop [2].in vivo: In Cyp4a14(-/-) mice, which display androgen-driven and 20-HETE-dependent hypertension, treatment with20-HETE antagonist abolished remodeling of renal resistance arteries measured as media thickness (24±1 vs. 15±1μm) and M/L (0.29±0.03 vs. 0.17±0.01) [4]. The transgenic mice had overexpressed hepatic CYP4F2, high hepatic 20-HETE and fasting plasma glucose levels but normal insulin level. The GP activity was increased and the cAMP/PKA-PhK-GP pathway was activated in the transgenic mice compared with wild-type mice [5]. Clinical trial: Mechanisms of Response to Diesel Exhaust in Subjects With Asthma. Phase not specified Human Endogenous Metabolite

对叶百部碱;Tuberostemonin 规格： 20mg

东莨菪内酯;Scopoletin 规格： 20mg

丁香酸;Syringic acid 规格： 20mg

丁香油;Clove oil 规格： 20mg

大黄酚;Chrysophanol;Chr 规格： 20mg

大豆苷元;Daidzein 规格： 20mg

3,5-二溴-4-羟基苯...3,5-Dibromo-4-hydroxybenzaldehyde,98%2973-77-55G

香芹酮L-Carvone,99%6485-40-125G

乙基香兰素Ethyl vanillin,≥98%121-32-425G

2-己烯醛trans-2-Hexen-1-al,98%6728-26-325ML

2,6-二甲基-5-庚烯醛2,6-Dimethyl-5-heptenal,97%106-72-925ML

反,反-2,4-壬二烯醛trans,trans-2,4-Nonadienal,≥89%5910-87-25ML