4-Butylresorcinol (Butylresorcinol)
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产品名称:
4-Butylresorcinol (Butylresorcinol)
产品型号:
GOY-Y0322
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-10
简单介绍
4-Butylresorcinol (Butylresorcinol)DMSO : 150 mg/mL (902.42 mM)
4-Butylresorcinol (Butylresorcinol)
的详细介绍
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性能参数
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产品名称
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4-Butylresorcinol (Butylresorcinol)
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规格
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10mM*1mL 50mg
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货号
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GOY-Y0322
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含量
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>98.00%
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CAS
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18979-61-8
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别名
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N/A
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化学名
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N/A
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分子式
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C10H14O2
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分子量
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分子 166.22
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溶解度
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DMSO : 150 mg/mL (902.42 mM)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM.
It shows that 4-Butylresorcinol (4-n-butylresorcinol) significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it is also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. 4-Butylresorcinol does not induce ERK, Akt activation, or MITF degradation, and has no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. 4-Butylresorcinol strongly reduces tyrosinase activity in a cell-free system. Moreover, 4-Butylresorcinol shows an additive effect in combination with hinokitiol, which reduces MITF expression[2].
[1]. Jiang Y, et al. Synthesis and biological evaluation of unsymmetrical curcumin analogues as tyrosinaseinhibitors. Molecules. 2013 Apr 3;18(4):3948-61. [2]. Kim DS, et al. Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis. Biol Pharm Bull. 2005 Dec;28(12):2216-9.
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