性能参数

产品名称

4-hydroperoxy Cyclophosphamide

规格

5g 25g 1g 10g

货号

GOY-Y0341

 含量

>95.00%

CAS

39800-16-3

别名

4-OOH-CY

化学名

2-[bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl, hydroperoxide

分子式

C7H15Cl2N2O4P

分子量

分子 293.1

溶解度

30mg/mL in DMSO,Souble in chloroform and dichloromethane. Prepare for immediate use. Do not store after dissloved

储存条件

Store at -80°C

General tips

用途

仅供科研

价格

电询

详细内容

4-hydroperoxy Cyclophosphamide (4-OOH-CY) is the active metabolite form of the prodrug Cyclophosphamide. 4-OOH-CY crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS).[1] Formulations containing the prodrug Cyclophosphamide are used to treat lymphomas and autoimmune disorders.[2],[3]

Reference:

[1]. Strauss, G., Westhoff, M.-A., Fischer-Posovszky, P., et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 15(2), 332-343 (2008).

[2]. Ahmed, A.R., and Hombal, S.M. Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical uses. J. Am. Acad. Dermatol. 11(6), 1115-1126 (1984).

[3]. Appel, G.B. New and future therapies for lupus nephritis. Cleve. Clin. J. Med. 79(2), 134-140 (2012).

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1,3,5,8-四羟基山酮 规格： HPLC≥98%;10mg

四氢姜黄素 规格： HPLC≥98%;20mg

鲨肌醇 规格： HPLC≥98%;20mg

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三尖杉碱 规格： HPLC≥98%;20mg

4-氯四氢吡喃4-Chlorotetrahydropyran,96%1768-64-55G

2-乙基呋喃2-Ethylfuran,≥99%3208-16-05G

3,4-环氧四氢呋喃3,4-Epoxytetrahydrofuran,98%285-69-85G

2,5-二甲氧基二氢呋喃2,5-Dimethoxy-2,5-dihydrofuran,97%332-77-425G

(S)-3-羟基四氢呋喃(S)-3-Hydroxytetrahydrofuran,99%86087-23-21G

3-羟基四氢呋喃3-Hydroxytetrahydrofuran,98%453-20-35G