性能参数

产品名称

4-Methylamino antipyrine hydrochloride

规格

25mg 50mg 100mg

货号

GOY-Y0364

 含量

>98.00%

CAS

856307-27-2

别名

N/A

化学名

N/A

分子式

C12H16ClN3O

分子量

分子 253.73

溶解度

N/A

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever[1][2][3]. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties[2].

Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important[2].

The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine[1].

轮环藤宁 规格： HPLC≥98%;20mg

龙胆山酮酚 规格： HPLC≥98%;10mg

雷公藤氯内酯醇 规格： HPLC≥98%;20mg

藜芦酸 规格： HPLC≥98%;20mg

龙血素C 规格： HPLC≥98%;20mg

龙血素A 规格： HPLC≥98%;20mg

2,5-二氯苯腈2,5-Dichlorobenzonitrile,97%21663-61-65G

2,4-二氯苯腈2,4-Dichlorobenzonitrile,98%6574-98-71G

2,3-二氯苯腈2,3-Dichlorobenzonitrile,98%6574-97-61G

4-甲氧基苯腈4-Methoxybenzonitrile,99%874-90-85G

3-羟基丙腈3-Hydroxypropionitrile,99%109-78-425G

3-乙酰苄腈3-Acetylbenzonitrile,97%6136-68-11G