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6(S)-Lipoxin A4

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产品名称: 6(S)-Lipoxin A4
产品型号: GOY-Y0406
产品展商: 谷研
产品文档: 无相关文档
发布时间:2023-04-10

简单介绍

6(S)-Lipoxin A4DMF: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml


6(S)-Lipoxin A4  的详细介绍

性能参数

产品名称

6(S)-Lipoxin A4

规格

25μg 50μg 100μg

货号

GOY-Y0406

 含量

>98.00%

CAS

94292-80-5

别名

N/A

 

 

化学名

N/A

分子式

C20H32O5

分子量

分子 352.5

溶解度

DMF: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml

储存条件

Store at -20°C

General tips

 

用途

仅供科研

价格

电询

详细内容

The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene. Lipoxin A4 (LXA4) was first described as a metabolite of 15-HpETE and/or 15-HETE when added in vitro to isolated human leukocytes. The material obtained in this manner consists of at least four distinct isomers: 5(S), 6(S); 5(S), 6(R); and the 11-trans and 11-cis isomers of each of these. 6(S)-LXA4 is one of the original four metabolites first identified by Serhan, Nicolaou, and Samuelsson. It was considered to be an artifact by these authors because it lacked the potency of the 5(S),6(R) isomer with respect to contraction of isolated guinea pig lung parenchymal strips. It has not been possible to isolate "natural" LXA4 from humans or other mammals in amounts sufficient for determination of absolute stereochemistry. Most authors refer to LXA4 as the 5(S),6(R), 11-cis isomer, but it is not clear that biological systems are aware of or agree with these conventions. Historically, conjugated tetraenes flanked by hydroxyl groups of mixed stereochemistry have been marketed as 'Lipoxin A4' by some biomolecular supply companies. The availability of single pure LXA4 enantiomers should help to reduce the confusion this has caused.

 

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