5-O-Demethylnobiletin
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产品名称:
5-O-Demethylnobiletin
产品型号:
GOY-Y0413
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-10
简单介绍
5-O-DemethylnobiletinSoluble in DMSO
5-O-Demethylnobiletin
的详细介绍
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性能参数
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产品名称
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5-O-Demethylnobiletin
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规格
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1mg 5mg
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货号
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GOY-Y0413
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含量
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>98.00%
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CAS
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2174-59-6
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别名
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N/A
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化学名
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N/A
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分子式
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C20H20O8
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分子量
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分子 388.37
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溶解度
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Soluble in DMSO
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储存条件
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4°C, protect from light
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].5-O-Demethylnobiletin (5-demethylnobiletin) promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[2]. IC50: 0.1 μM (Lox 5); 0.35 μM (LTB4) (5-O-Demethylnobiletin)[1]
[1]. Bas E, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72(2):136-42. [2]. Chiu SP, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61(39):9453-63.
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