性能参数

产品名称

6-Formylpterin

规格

500μg 1mg 5mg

货号

GOY-Y0426

 含量

>98.00%

CAS

712-30-1

别名

N/A

化学名

N/A

分子式

C7H5N5O2

分子量

分子 191.1

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid. It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in "hetero-substrate" inhibition at nanomolar concentrations. However, 6-formylpterin itself is converted by XO to 6-carboxylpterin and H2O2 and the turnover rate of this reaction can actually be accelerated by prior binding of a hetero-substrate to XO. In this way, 6-formylpterin acts as an intracellular generator of H2O2 in cells expressing XO, altering cellular function.

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