6-Methylmercaptopurine
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产品名称:
6-Methylmercaptopurine
产品型号:
GOY-Y0432
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-10
简单介绍
6-MethylmercaptopurineDMF: 15 mg/ml,DMSO: 30 m/gml
6-Methylmercaptopurine
的详细介绍
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性能参数
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产品名称
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6-Methylmercaptopurine
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规格
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50mg 100mg 250mg 1g
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货号
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GOY-Y0432
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含量
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>95.00%
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CAS
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50-66-8
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别名
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N/A
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化学名
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N/A
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分子式
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C6H6N4S
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分子量
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分子 166.2
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溶解度
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DMF: 15 mg/ml,DMSO: 30 m/gml
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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6-Methylmercaptopurine (6-MMP) is a metabolite of the purine synthesis and interconversion inhibitor 6-mercaptopurine .1 It is formed from 6-MP via methylation by thiopurine S-methyltransferase. Levels of 6-MMP are increased in patients with altered thiopurine metabolism and associated with therapeutic resistance to 6-MP.2
1.Rieder, M.J., and Carleton, B.Pharmacogenomics and adverse drug reactions in childrenFront. Genet.578(2014) 2.van Egmond, R., Chin, P., Zhang, M., et al.High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatmentAliment. Pharmacol. Ther.35(10)1181-1189(2012)
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