性能参数

产品名称

7α-Thiospironolactone

规格

500μg 1mg 5mg 10mg

货号

GOY-Y0438

 含量

>90.00%

CAS

38753-76-3

别名

N/A

化学名

N/A

分子式

C22H30O3S

分子量

分子 374.5

溶解度

Ethanol: soluble

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

7α-Thiospironolactone (7α-Thio-SL) is an active metabolite of the synthetic steroid spironolactone.1 In vivo, 7α-thio-SL (100 mg/kg) decreases plasma testosterone and estradiol levels in male dogs.2 It reduces mercuric chloride-induced nephrocalcinosis and mortality in rats.3

1.Los, L.E., Coddington, A.B., Ramjit, H.G., et al.Identification of spironolactone metabolites in plasma and target organs of guinea pigsDrug Metab. Dispos.21(6)1086-1090(1993) 2.Menard, R.H., Loriaux, D.L., Bartter, F.C., et al.The effect of the administration of spironolactone on the concentration of plasma testosterone, estradiol and cortisol in male dogsSteroids31(6)771-782(1978) 3.Szabo, S., and Gagnon, M.J.The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in ratsGen. Pharmacol.14(2)269-272(1983)

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