7-hydroxy Methotrexate (sodium salt)
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产品名称:
7-hydroxy Methotrexate (sodium salt)
产品型号:
GOY-Y0447
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-10
简单介绍
7-hydroxy Methotrexate (sodium salt)3mg/mL in DMSO, 14mg/mL in DMF
7-hydroxy Methotrexate (sodium salt)
的详细介绍
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性能参数
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产品名称
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7-hydroxy Methotrexate (sodium salt)
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规格
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500μg 1mg
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货号
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GOY-Y0447
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含量
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>96.00%
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CAS
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N/A
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别名
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7-hydroxy MTX
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化学名
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N-[4-[[(2,4-diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid, trisodium salt
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分子式
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C20H22N8O6?3Na
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分子量
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分子 539.4
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溶解度
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3mg/mL in DMSO, 14mg/mL in DMF
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储存条件
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Store at 4°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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7-hydroxy Methotrexate (7-hydroxy MTX) is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases.[1] Elimination of 7-hydroxy MTX is associated with the multi-drug transporters Abcc2, Abcc3, and Abcg2 in transgenic mouse models. It and the parent compound rapidly accumulate when all three transporters are absent.[2] Formulations containing methotrexate have been used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions.[3],[4] Various methods have been described to quantify 7-hydroxy MTX levels during cancer therapy to avoid toxicity.[5],[6]
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