8-iso Prostaglandin F2α
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产品名称:
8-iso Prostaglandin F2α
产品型号:
GOY-Y0464
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-10
简单介绍
8-iso Prostaglandin F2αDMF: >100 mg/ml,DMSO: >100 mg/ml,Ethanol: >100 mg/ml,PBS pH 7.2: 3 mg/ml
8-iso Prostaglandin F2α
的详细介绍
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性能参数
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产品名称
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8-iso Prostaglandin F2α
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规格
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1mg 5mg 10mg
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货号
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GOY-Y0464
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含量
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>98.00%
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CAS
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27415-26-5
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别名
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N/A
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化学名
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9α,11α,15S-trihydroxy-(8β)-prosta-5Z,13E-dien-1-oic acid
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分子式
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C20H34O5
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分子量
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分子 354.5
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溶解度
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DMF: >100 mg/ml,DMSO: >100 mg/ml,Ethanol: >100 mg/ml,PBS pH 7.2: 3 mg/ml
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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8-iso PGF2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10-6 M) and I-BOP (3 x 10-7 M) with IC50 values of 1.6 x 10-6 M and 1.8 x 10-6 M, respectively.
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