性能参数

产品名称

Adjudin

规格

5mg 10mg 50mg 100mg

货号

GOY-Y0522

 含量

>98.00%

CAS

252025-52-8

别名

N/A

化学名

N/A

分子式

C15H12Cl2N4O

分子量

分子 335.19

溶解度

DMSO : ≥ 34 mg/mL (101.44 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Adjudin is an extensively studied male contraceptive with a superior mitochondria-inhibitory effect. Adjudin is also a potent Cl- channel blocker.

Adjudin is a potent blocker of Cl- channels: disrupting Cl- ion transport function results in a decline in sperm capacitation and fertilizing ability in humans in vitro[1]. Adjudin (ADD) is a mitochondria inhibitor[2]. Adjudin is a molecule that mediates adherens junction disruption at the Sertoli-germ cell interface. To investigate the effect of Adjudin on cancer cells, more than ten different types of human or mice cancer cell lines are treated with increasing concentrations of Adjudin and the cell proliferation is measured by the modified MTT assay. Adjudin inhibits cell proliferation in a dose dependent manner in SGC-7901 (human gastric adenocarcinoma cell), MDA-MB-231 (human breast adenocarcinoma cell), Smmc-7721 (human hepatoma cell) and MIA Paca-2 (human pancreatic adenocarcinoma cell) cells. The IC50 of Adjudin is determined to be 58.0 uM, 13.8 uM, 72.3 uM and 52.7 uM against SGC-7901, MDA-MB-231, Smmc-7721 and MIA Paca-2 cells, respectively, after treatment for 24 h. Similar results are obtained in other human and mice cancer cell lines. The IC50 of Adjudin in A549 cells and PC3 cells is 63.1 uM and 93.0 uM, respectively. For WI-38 and BPH-1 cells, the IC50 of Adjudin can be observed at more than 300 uM and 200 uM, respectively, which is about 5 times and 2 times more than that for the cancer cell lines A549 and PC3[3].

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