all-trans-4-hydroxy Retinoic Acid
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产品名称:
all-trans-4-hydroxy Retinoic Acid
产品型号:
GOY-Y0537
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-11
简单介绍
all-trans-4-hydroxy Retinoic AcidChloroform: Slightly Soluble,Methanol: Slightly Soluble
all-trans-4-hydroxy Retinoic Acid
的详细介绍
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性能参数
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产品名称
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all-trans-4-hydroxy Retinoic Acid
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规格
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1mg
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货号
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GOY-Y0537
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含量
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>98.00%
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CAS
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66592-72-1
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别名
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N/A
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化学名
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4-hydroxy-retinoic acid
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分子式
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C20H28O3
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分子量
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分子 316.4
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溶解度
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Chloroform: Slightly Soluble,Methanol: Slightly Soluble
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1. It binds to retinoic acid receptors (RARs) with a lower affinity than other all-trans retinoic acid metabolites (IC50s = 606, 298, and 892 nM for RARα, RARβ, and RARγ, respectively, in a radioligand binding assay). It also transactivates RARs with a lower efficacy than other metabolites (EC50s = 791, 64, and 94 nM for RARα, RARβ, and RARγ, respectively) but induces transcription of a reporter plasmid equipotently. all-trans-4-hydroxy Retinoic acid inhibits cell growth, halts the cell cycle in the G1 phase, and induces differentiation of NB4 acute promyelocytic leukemia cells (EC50 = 79.8 nM).
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