Alternariol monomethyl ether
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产品名称:
Alternariol monomethyl ether
产品型号:
GOY-Y0557
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-11
简单介绍
Alternariol monomethyl etherDichloromethane: soluble,Methanol: soluble
Alternariol monomethyl ether
的详细介绍
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性能参数
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产品名称
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Alternariol monomethyl ether
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规格
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1mg 5mg
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货号
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GOY-Y0557
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含量
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>98.00%
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CAS
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23452-05-3
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别名
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N/A
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化学名
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3,7-dihydroxy-9-methoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one
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分子式
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C15H12O5
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分子量
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分子 272.3
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溶解度
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Dichloromethane: soluble,Methanol: soluble
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. brassicae extracts. AME is a common contaminant in cereal grains such as wheat, barley, and sorghum that is cytotoxic to bacterial (MIC = 500 μg/disc for B. mycoides in a bacterial halo assay) and mammalian cells (IC50 = 120 μM in HCT116 cells). It inhibits human topoisomerase II and bacterial gyrase at initial inhibitory concentrations of 25 and 10 μM, respectively. AME selectively inhibits monoamine oxidase A (MOA-A; Ki = 0.34 μM). AME also provokes DNA damage that induces mitochondrial permeability transition pore-mediated activation of apoptosis.
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