性能参数

产品名称

15(R)-Lipoxin A4

规格

25μg 50μg 100μg 250μg

货号

GOY-Y0582

 含量

>95.00%

CAS

171030-11-8

别名

AT-Lipoxin A4

化学名

5(S),6(R),15(R)-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid

分子式

C20H32O5

分子量

分子 352.5

溶解度

DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml

储存条件

Store at -80°C

General tips

用途

仅供科研

价格

电询

详细内容

Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2]  15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15(R)-LXA4 to regulate leukocyte function.[4] 15(R)-LXA4 is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.[5]

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