性能参数

产品名称

17(R)-Resolvin D1

规格

10μg 25μg 50μg 100μg

货号

GOY-Y0585

 含量

>95.00%

CAS

528583-91-7

别名

Aspirin-triggered Resolvin D1

化学名

7S,8R,17R-trihydroxy-4Z,9E,11E,13Z,15E19Z-docosahexaenoic acid

分子式

C22H32O5

分子量

分子 376.5

溶解度

0.05mg/mL in PBS, pH 7.2

储存条件

Store at -80°C

General tips

用途

仅供科研

价格

电询

详细内容

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).[3] 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.[3] In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. Analytical and biological comparisons of synthetic 17(R)-RvD1 with endogenously derived 17(R)-RvD1 have confirmed its identity as matching the natural product.[4]

1,2,3-Trieicosapentaenoyl-rac-glycerol CS-01Y63291 1mg 5mg 10mg 25mg >98.00% 99660-94-3

(S)-Nornicotine CS-01Y63292 5mg >98.00% 494-97-3

(S)-Leucic acid CS-01Y63293 1g >98.00% 13748-90-8

(S)-Laudanosine CS-01Y63294 1mg 5mg >98.00% 2688-77-9

(S)-GNE-140 CS?

烟酸Nicotinic acid59-67-625G

核糖核酸酶抑制剂Ribonuclease InhibitorN/A2.5KU

刀豆蛋白A-琼脂糖凝...Con A Sepharose 4BN/A25ML

尼泊金丙酯钠Propyl 4-hydroxybenzoate sodium salt35285-69-9500G

苯基-琼脂糖凝胶 6F...Phenyl-Sepharose 6 Fast Flow，low subN/A50ML

QAE-葡聚糖凝胶 A-25QAE Sephadex? A-2552219-08-625G