性能参数

产品名称

Antimycin A2

规格

500μg

货号

GOY-Y0601

 含量

>98.00%

CAS

27220-57-1

别名

N/A

化学名

(2R,3S,6S,7R,8R)-3-(3-formamido-2-hydroxybenzamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl butyrate

分子式

C27H38N2O9

分子量

分子 534.6

溶解度

DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Antimycin A2 is an active component of the antimycin A antibiotic complex. Antimycin A2 inhibits electron transport and exhibits antibiotic properties. It also inhibits ATP-citrate lyase with a Ki value of 4.2 uM. The antimycin A complex is a mixture of antimycins A1, A2, A3, and A4 that demonstrates antifungal, insecticidal, nematocidal, and piscicidal properties. It blocks mitochondrial respiration and can deplete cellular levels of ATP via inhibition of complex III of the mitochondrial electron transport chain (ETC). Antimycin A prevents the transfer of electrons between the b-cytochromes and ubiquinone at the Q(inner) site of complex III. This results in the stabilization of the ubisemiquinone radical at the Q(outer) site of complex III, leading to increased production of superoxide. Antimycin A is widely used in research to shunt electron flow through the ETC to study the chemical details of oxygen respiration. Additionally, antimycin A has been shown to inhibit Bcl-2 and Bcl-xL proteins, inducing apoptosis.

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