性能参数

产品名称

AP39

规格

5mg 10mg 25mg 1mg

货号

GOY-Y0606

 含量

>95.00%

CAS

1429173-57-8

别名

N/A

化学名

N/A

分子式

C37H38O2PS3

分子量

分子 641.9

溶解度

DMF: 5 mg/ml,DMSO: 20 mg/ml,Ethanol: 16 mg/ml,PBS (pH 7.2): 1 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Under oxidative stress conditions induced by glucose oxidase, AP39 has antioxidant and cytoprotective effects. AP39 is effective in vivo, inhibiting voltage-dependent T-type calcium channels and improving hemodynamic parameters in rats.

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2-Amin?

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二氢黄酮甙Hesperidin,≥80.0%520-26-325G

D(-)-水杨苷D(-)-Salicin, ≥99%138-52-35G

七叶苷（倍半水）Esculin sesquihydrate ,≥98.0%66778-17-41G

1，10-癸二硫醇1,10-Decanedithiol1191-67-95G

1,9-壬二硫醇1,9-Nonanedithiol,≥95.0%3489-28-91G