性能参数

产品名称

Apoptosis Activator 2

规格

50mg 10mg 100mg 25mg

货号

GOY-Y0610

 含量

>98.00%

CAS

79183-19-0

别名

化学名

1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione

分子式

C15H9Cl2NO2

分子量

分子 306.1

溶解度

DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS(pH 7.2) (1:4): 0.25 mg/ml,Ethanol: 1 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Apoptosis Activator 2 is a small molecule apoptosis activator with IC50 value of about 4μM [1].

Apoptosis Activator 2 is a cell permeable compound that promotes apoptosis by activating caspases in a cytochrome c- and Apaf-1-dependent manner. 20μM Apoptosis Activator 2 increases the fraction of Apaf-1 in the apoptosome when there is 0.15μM cytochrome c. It is found to induce the oligomerization of Apaf-1. Through the induction of apoptosis, Apoptosis Activator 2 notably induces caspase-3 activation, PARP cleavage and DNA fragmentation. Moreover, this induction of apoptosis only occurs in tumor cell lines (such as breast, lung, colon, and epidermal cancer cell lines). Normal cell lines are resistant to Apoptosis Activator 2 [1, 2].

References:

[1] Nguyen JT, Wells JA. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8.

[2] Nguyen TV, Jayaraman A, Quaglino A, Pike CJ. Androgens selectively protect against apoptosis in hippocampal neurones. J Neuroendocrinol. 2010 Sep;22(9):1013-22.

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2-T?

3-甲氧基苯硫酚3-Methoxythiophenol,≥98.0 %15570-12-41G

2-甲氧基苯硫酚2-Methoxythiophenol,≥97.0 %7217-59-61G

4-异丙基苯硫酚4-Isopropylbenzenethiol, ≥96.0 %4946-14-95G

3,4-二甲基苯硫酚3,4-Dimethylbenzenethiol,≥97.0 %18800-53-81G

2,5-二甲基苯硫酚2,5-Dimethylbenzenethiol,≥98.0 %4001-61-05G

4-溴苯硫酚4-Bromothiophenol,≥97.0%106-53-65G