性能参数

产品名称

Apoptosis Inhibitor

规格

10mg 100mg 25mg

货号

GOY-Y0611

 含量

>98.00%

CAS

54135-60-3

别名

N/A

化学名

2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione

分子式

C13H16O4

分子量

分子 236.3

溶解度

≥ 9.1mg/mL in DMSO

储存条件

Store at 4°C

General tips

用途

仅供科研

价格

电询

详细内容

M50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1]

In human Fas-expressing WC8 cells, M50054 inhibited apoptosis by soluble human Fas ligand in vitro cell death assay. M50054 inhibited the apoptotic U937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. M50054 inhibited apoptotic characters such as DNA phosphatidylserine and fragmentation exposure in these cells. These anti-apoptotic effects were dependent on inhibition of caspase-3 activation. Additionally, M50054 significantly inhibited anti-Fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. Alopecia (hair loss) symptoms were also significantly improved with topical treatment with M50054. M50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia. [1]

Reference:

[1].Tsuda T, Ohmori Y, Muramatsu H et al. Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia.Eur J Pharmacol. 2001 Dec 14;433(1):37-45.

20-HETE CS-01Y63447 25μg 50μg 100μg 500μg >98.00% 79551-86-3

20-hydroxy Leukotriene B4 CS-01Y63448 25μg 50μg 100μg >97.00% 79516-82-8

21-hydroxy Eplerenone CS-01Y63449 1mg >98.00% 334678-67-0

21-Hydroxypregnenolone CS-01Y63450 10mg 10mM >98.00% 1164-98-3

?

2-溴苯硫醇2-Bromothiophenol16144041G

2,5-二氯苯硫酚2,5-Dichlorobenzenethiol,≥98.0%(GC)5858-18-41G

2,3-二氯苯硫酚2,3-Dichlorothiophenol,≥97.0 %17231-95-75G

4-氯苯硫酚4-Chlorothiophenol,≥98.0 %106-54-75G

3-氯苯硫酚3-Chlorobenzenethiol,≥97.0 %2037-31-21G

2-氯苯硫酚2-Chlorothiophenol, ≥98.0%16144345G