性能参数

产品名称

AS-2077715

规格

1mg

货号

GOY-Y0626

 含量

>70.00%

CAS

1637356-98-9

别名

N/A

化学名

N/A

分子式

C25H41NO7

分子量

分子 467.6

溶解度

Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

AS-2077715 is a fungal metabolite and an inhibitor of fungal mitochondrial complex III (cytochrome bc1; IC50 = 80 ng/ml for T. mentagrophytes complex III).1 It is selective for fungal over mammalian complex III (IC50s = 480 and 860 ng/ml for murine EL-4 cell and human Jurkat cell complex III, respectively). AS-2077715 inhibits ATP production in (IC50 = 0.33 μg/ml) and is fungicidal against T. mentagrophytes when used at concentrations of 1 and 10 μg/ml. In vivo, AS-2077715 (10 and 20 mg/kg) reduces the number of foot pad skin colony forming units (CFUs) in a guinea pig model of T. mentagrophytes infection.2

1.Ohsumi, K., Watanabe, M., and Fujie, A.AS2077715 Is a selective inhibitor of fungal mitochondrial cytochrome Bc? complexJ. Antibiot. (Tokyo)67(10)713-716(2014) 2.Ohsumi, K., Murai, H., Nakamura, I., et al.Therapeutic efficacy of AS2077715 against experimental tinea pedis in guinea pigs in comparison with terbinafineJ. Antibiot. (Tokyo)67(10)717-719(2014)

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4’-hydroxy Trazodone CS-01Y63538 1mg >95.00% 53818-10-3

4',5-Dihydroxyflavone CS-01Y63539 10mM*1mL 10mg 50mg >9?

α-环糊精α-Cyclodextrin,≥98.0% (HPLC)10016-20-31G

2-羟丙基-β-环糊精(2-Hydroxypropyl)-β-cyclodextrin ,≥9...128446-35-55G

2,6-二-O-甲基-β-...2,6-Di-O-methyl-β-cyclodextrin,≥98%51166-71-31G

γ-环糊精γ-Cyclodextrin,≥98.0% (HPLC)17465-86-01G

β-环糊精β-Cyclodextrin,>98.0% (HPLC)7585-39-925G

糊精Dextrin9004-53-9500G