性能参数

产品名称

Arimoclomol maleate 

规格

5mg 1mg

货号

GOY-Y0632

 含量

>98.00%

CAS

No. 289893-26-1

别名

N/A

化学名

N/A

分子式

C18H24ClN3O7

分子量

分子 429.85

溶解度

DMSO: 250 mg/mL (581.60 mM); H2O: 100 mg/mL (232.64 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP).

The HSP coinducer Arimoclomol (BRX-220), administered for 5 d, has a protective effect against CCK-induced acute pancreatitis. Repeated CCK treatment results in the typical laboratory and morphological changes of experimentally induced pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased in the animals treated with Arimoclomol [1]. Arimoclomol is a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease[2].

[1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92. [2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96.

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