性能参数

产品名称

Romidepsin (FK228, depsipeptide)

规格

10mM (in 1mL DMSO) 1mg 5mg

货号

GOY-Y2817

 含量

>98.00%

CAS

128517-07-7

别名

Istodax, Antibiotic FR 901228, FK228, FR 901228, FK-228,Romidepsin

化学名

(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone

分子式

C24H36N4O6S2

分子量

分子量 540.7

溶解度

≥ 27.035mg/mL in DMSO, ≥ 35.27 mg/mL in EtOH with ultrasonic

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Romidepsin, also known as FK228 or depsipeptide, is potent and selective inhibitor of histone deacetylases (HDACs) which are associated with the regulation of re-expression of silenced tumor suppressor genes. It was the first HDAC inhibitor to manifest anti-tumor activity and originally isolated from a rod-shaped Gram-negative bacterium, Chromobacterium violaceum, found in a Japanese soil sample. Romidepsin exhibits a stronger inhibition towards HDAC1 and HDAC2 enzymes (class I), removing acetyl groups from the lysine residues of N-terminal histone tails and maintaining a more open and transcriptionally active chromatin state, than HDAC4 and HDAC6 enzymes (class II). Besides HDAC inhibition, romidepsin is also able to induce cell cycle arrest, cellular differentiation, apoptosis and alteration of gene expression in  malignancies.

L-天冬酰胺，无水物 99%  氟化钡 99.99% metals basis,10μm

L-天冬酰胺 一水合物  99%  氟化钡 99.999% metals basis

DL-天冬酰胺,一水 99%  磷酸氢锶 荧光级，99%

L-胱氨酸盐酸盐 BR  磷酸氢锶 99.98% metals basis

DL-谷氨酸 98%  硫氰酸亚铜 99%

DL-谷氨酸 for cell culture，≥98.0%  硫氰酸钾 CP,98%

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Acetyl Tetrapeptide-310mg 25mg 50mg 100mg>95.00%Cas No. 827306-88-7C22H39N9O5

BPC 157 (acetate)1 mg 5 mg 10 mg 25 mg>95.00%Cas No. 1628202-19-6C62H98N16O22.XC2H4O2

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CAY105545mg 10mg 25mg 50mg>95.00%Cas No. 267654-00-2C14H16N2OS

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FR9003591 mg>95.00%Cas No. 107530-18-7C49H75N7O15