性能参数

产品名称

SDZ 224-015

规格

5 mg 10 mg 25 mg

货号

GOY-Y2823

 含量

>98.00%

CAS

161511-45-1

别名

N/A

化学名

N/A

分子式

C30H35Cl2N3O9

分子量

分子量 652.52

溶解度

N/A

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM)[1][2].

SDZ 224-015 (0.3-300 μg/kg) potently reduces carrageenin-induced paw oedema[2].SDZ 224-015 (0.2-5 mg/kg, p.o.) displays analgesic activity in the Randall-Selitto yeast-inflamed paw pressure test, significant at a dose of 1 mg/kg[2].

[1]. Martin A Redhead, et al. Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Sci Rep. 2021 Jun 24;11(1):13208.

[2]. P R Elford, et al. Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin-1 beta converting enzyme. Br J Pharmacol. 1995 Jun;115(4):601-6.

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叶酸 用于细胞和昆虫细胞培养，≥97%  三乙二醇 75℃＋＋＋

溴化铵 AR,99.0%  三乙二醇 CP

溴乙烷 AR,98%  三乙二醇 99%

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溴乙烷 CP,97%  乙腈 >99.5%(GC)

十溴二苯乙烷 96%  二乙二醇 CP

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