性能参数

产品名称

Solasodine

规格

25mg 50mg 100mg

货号

GOY-Y2827

 含量

>98.00%

CAS

126-17-0

别名

Purapuridine;Solancarpidine;Solasodin

化学名

5',6a,8a,9-tetramethyl-1,3,4,5,6,6a,6b,7,8,8a,8b,9,11a,12,12a,12b-hexadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-piperidin]-4-ol

分子式

C27H43NO2

分子量

分子量 413.64

溶解度

≥ 20.7 mg/mL in EtOH

储存条件

4°C, protect from light

General tips

用途

仅供科研

价格

电询

详细内容

Description: IC50 Value: 12.17 ± 3.3 uM (Hela cell line)[1] Solasodine is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and human myeloid leukemia cell line (U937). in vitro: Mouse embryonic teratocarcinoma P19 cells exposed to solasodine for 2 days followed by a 5-day washout differentiated into cholinergic neurons that expressed specific neuronal markers and displayed important axonal formation that continued growing even 30 days after treatment [2]. in vivo: A 2-week infusion ofsolasodine into the left ventricle of the rat brain followed by a 3-week washout resulted in a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining, demonstrating the proliferative and differentiating properties of solasodine on neuronal progenitors. Solasodine treatment in rats resulted in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells, suggesting a possible role played by neurosteroid production in solasodine-induced neurogenesis. In GAD65-GFP mice that express the green fluorescent protein under the control of the glutamic acid decarboxylase 65-kDa promoter, solasodine treatment increased the number of GABAergic progenitors and neuroblasts generated in the subventricular zone and present in the olfactory migratory tract [2]. intraperitoneal (i.p.) injection of solasodine (25 mg/kg) significantly delayed (p < 0.01) latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. In the MES model, solasodine significantly reduced (p < 0.001) duration of HLTE at 25, 50, and 100 mg/kg, i.p. in a dose-dependent manner [3]. Oral administration (80 mg/kg body wt/day for 30 days) of solasodine (extracted and isolated from the berries of the Solanum xanthocarpum) to intact dogs significantly decreased the epithelial cell height of cauda epididymides [4]. Toxicity: N/A Clinical trial: N/A

对氯苯酚 CP，98%  丙位癸内酯 98%

邻氯苯酚 CP  丙位癸内酯 ≥98%, FCC, FG

2,4-二氯苯酚  >98.0%(GC)  丙位十二内酯  98%

2,6-二氯苯酚 AR,99.0%  丙位十二内酯  分析标准品,≥98.5% (GC)

2,4,6-三氯苯酚 98%  丙位十二内酯  98%, FCC, Kosher

氯碘甲烷, 含稳定剂铜, 97%  十二腈  98%

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Adenosine 5′-diphosphoribose sodium10mg>98.00%Cas No. 68414-18-6 N/AC?

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Wogonoside20mg>98.00%Cas No. 51059-44-0C22H20O11

Wogonin20mg>98.00%Cas No. 632-85-9C16H12O5