性能参数

产品名称

Stattic

规格

10mM (in 1mL DMSO) 25mg 100mg

货号

GOY-Y2834

 含量

>98.00%

CAS

19983-44-9

别名

N/A

化学名

6-nitro-1-benzothiophene 1,1-dioxide

分子式

C8H5NO4S

分子量

分子量 211.19

溶解度

≥ 10.6mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Stattic is a small molecule inhibitor of STAT3 with IC50 values of 2.562 ± 0.409 μM, 3.481 ± 0.953 μM, 2.282 ± 0.423 μM and 2.648 ± 0.542 μM, respectively, in UM-SCC-17B, OSC-19, Cal33 and UM-SCC-22B cell lines [1].

Stattic is reported to selectively inhibit dimerization, activation and nuclear translocation of STAT3. It can also induce the apoptosis of STAT3-dependent breast cancer cell lines [2].

The inhibition of STAT3 by Stattic results in decreased STAT3-mediated HIF-1 expression and subsequent radiosensitization of HNSCC cells. Inhibiting the STAT3 signaling pathway may represent an effective strategy in the treatment of HNSCC. The evidence of Stattic activity in vivo has also been found. Stattic pre-treatment sensitizes orthotopic xenograft HNSCC tumors to radiation, wich results in signi?cantly reduced tumor growth, although this effect was not as dramatic as anticipated by the in vitro studies [1].

切片石蜡 病理级，熔点58～60℃  三氧化钨 99.99% metals basis

D-生物素 98%  三氧化钨 比表面积15m2/g, 50nm,99.9%

甲基三氧化铼 98%  三氧化钨 99.8% metals basis

鸡蛋白蛋白 98%  4-溴苯甲酰氯 96%

鸡蛋白蛋白 90%  对氯苯乙酮 97%

过氧化氢酶  3500 units/mg   苄胺 AR,99.00%

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A 4849545mg 25mg 50mg>98.00%Cas No. 142557-61-7C13H15N5O3