性能参数

产品名称

Tamoxifen Citrate

规格

10mM (in 1mL DMSO) 5g 10g

货号

GOY-Y2838

 含量

>98.00%

CAS

54965-24-1

别名

N/A

化学名

2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid

分子式

C32H37NO8

分子量

分子量 563.64

溶解度

≥ 28.2mg/mL in Etoh with gentle warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Tamoxifen Citrate (ICI 46474) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[1][2][3].Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[4].

Tamoxifen Citrate (ICI 46474) shows strong inhibition of MCF-7 cells (EC50=1.41 μM) and to a lesser extent the T47D cells (EC50=2.5 μM) but does not affect the MDA-MB-231 cells[2].

The Tamoxifen Citrate-inducible gene knockout strategy has clear advantages in that expression of a gene can be ablated in  mice at will in a tissue specific manner. To study the role of Med1 in  heart, 7-week old TmcsMed1-/- mice are given a daily Iintraperitoneal injection of Tamoxifen Citrate at a dose of 65 mg/kg for 5 days and killed at selected intervals thereafter. qPCR analysis of RNA shows that the Med1 expression begin to decrease after 3 days of Tamoxifen Citrate injection (about 70% decrease), and by 5 days of injection, Med1 expression is almost non-detectable in the heart. Tamoxifen Citrate-inducible cardiac-specific disruption of Med1 (TmcsMed1-/-) in  mice causes dilated cardiomyopathy[3].

切片石蜡 病理级，熔点54～56℃  氧化硼 99.99% metals basis

切片石蜡 病理级，熔点56～58℃  氧化硼 99.999% metals basis

切片石蜡 病理级，熔点58～60℃  氧化硼 AR,98%,200目

切片石蜡 病理级，熔点60-62℃  氧化硼 99.9% metals basis,200目

切片石蜡 病理级，熔点62-64℃  氧化镓 99.99% metals basis

4-氨基-6-氯嘧啶  98%  氧化镓 99.999% metals basis

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