性能参数

产品名称

Vandetanib 

规格

10mM (in 1mL DMSO) 25mg 100mg

货号

GOY-Y2849

 含量

>98.00%

CAS

443913-73-3

别名

ZD6474

化学名

N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

分子式

C22H24BrFN4O2

分子量

分子量 475.35

溶解度

≥ 11.9mg/mL in DMSO with gentle warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

ZD6474 is a dual inhibitor of VEGFR-2 and EGFR with IC50 values of 40 nM and 500 nM, respectively [1].

ZD6474 showed potent inhibition activities against recombinant VEGFR-2 and EGFR in the in vitro assays. The inhibition of VEGFR-2 was 2.7-fold more potent than that of VEGFR-3 (Flt-4) kinase and 40-fold more potent than that of VEGFR-1. In human umbilical vein endothelial cells, treatment of ZD6474 resulted in significant inhibition of cell proliferation stimulated by VEGF and EGF with IC50 values of 60 and 170 nM, respectively. Through inhibiting the kinase activity of EGFR, ZD6474 can inhibit cell growth of various cancer cell lines, including lung, ovarian, breast and colon cancers. Besides that, ZD6474 administration inhibited tumor growth in a dose-dependent manner in many tumor xenograft models.

吡虫啉 分析标准品，98.5%  氟化锂  99.9% metals basis

吡虫啉标准溶液 1.00mg/ml  结晶氯化锂 AR,97.0%

稻瘟灵标准溶液 0.100mg/ml  双(**基硅烷基)氨基锂 95%

稻瘟灵 分析标准品，97.5%  双(**基硅烷基)氨基锂 1.0 M in THF

稻瘟灵标准溶液100μg/ml,u=2%,溶剂:正己烷  金属锂粒 99.9% metals basis

稻瘟灵标准溶液10μg/ml,u=2%,溶剂:正己烷  金属锂棒 99.9% metals b?

EACC10mM*1mL in DMSO 5mg 10mg 50mg 100mg>98.00%Cas No. 864941-31-1C13H11N3O6S2

GLPG18371mg 5mg 10mg 50mg 100mg>98.00%Cas No. 1654725-02-6C16H20N4O3S

MDV3100 (Enzalutamide)10mM (in 1mL DMSO) 5mg 10mg 25mg 50mg>98.00%Cas No. 915087-33-1C21H16F4N4O2S

RA1905mg 10mg 25mg 50mg 100mg>98.00%Cas No. 1617495-03-0C28H23Cl5N2O2

SMER182mg 5mg 10mg 50mg 100mg>98.00%Cas No. 944153-47-3C16H14ClNO2

SMER 35 mg 10 mg 25 mg 50 mg 100 mg>98.00%Cas No. 67200-34-4C11H4N4O2

SR90112mg 5mg 10mg 50mg 100mg>98.00%Cas No. 1379686-29-9C23H31ClN4O3S