性能参数

产品名称

Maytansinol (Ansamitocin P-0)

规格

10mM*1mLinDMSO 5mg 10mg 50mg

货号

GOY-Y2870

 含量

>98.00%

CAS

57103-68-1

别名

N/A

化学名

N/A

分子式

C28H37ClN2O8

分子量

分子量 565.06

溶解度

DMSO : ≥ 35 mg/mL (61.94 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.Target: Microtubule/Tubulinin vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug.

[1]. Edwards A, et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503.

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正辛烷 CP,95%  铝 99.95%，1-2 μm，球形

1-辛硫醇 98%  纳米铝粉 99.9% metals basis:,粒径：50nm

1-辛烯 98%  水质铝标样 analytical standard,0.286mg/l,in water  u=0.031%

1-辛烯 分析标准品，≥99.5% (GC  针式打印机 LQ-630

1-十八烯 90%  色带 800开票机专用

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