性能参数

产品名称

Mebendazole

规格

10mM (in 1mL DMSO) 25g 50g 100g

货号

GOY-Y2874

 含量

>98.00%

CAS

31431-39-7

别名

NSC 184849,R 17635

化学名

N-(6-benzoyl-1H-benzimidazol-2-yl)-carbamic acid, methyl ester

分子式

C16H13N3O3

分子量

分子量 295.3

溶解度

≥ 13mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Mebendazole is a broad-spectrum microtubule-disrupting anthelmintic that is active against  or larval cestodes, and human intestinal nematodes [1][2]. Mebendazole had good potency against Giardia isolates with IC50 for a 24-h was 0.19 μM and for a 4-h exposure was 2.7 μM, respectively. And inhibition of Giardia growth in vitro was maintained beyond 72 to 96 h [2].

Mebendazole is a broad-spectrum anthelmintic and a tubulin-disrupting agent. Mebendazole inhibited melanoma growth with an average IC50 of 0.32 μmol/L and induced apoptosis through the intrinsic and extrinsic mitochondrial pathways. In melan-a, M-14, and SK-Mel-19 cells, Mebendazole caused overall microtubular network disarray. In M-14 and SK-Mel-19 melanoma cells, Mebendazole led to Bcl-2 phosphorylation, which then promoted melanoma apoptosis [3]. In human lung cancer cell lines, Mebendazole arrested cells at the G2-M phase before the onset of apoptosis [4]. Also, Mebendazole potently inhibited Hh signaling and slowed the growth of Hh-driven human medulloblastoma cells [6]. Additionally, mebendazole stabilized the transcriptional activator HIF-1α and its downstream targets, preventing oxidative neuronal death in primary neurons [7].

In nu/nu mice bearing human tumor xenografts, Mebendazole inhibited tumor growth and significantly reduced the number and size of tumors [4][5].

二乙烯苯 50%  呋喃西林 98%

二乙烯苯 55%  硫酸铝，十八水 Ph. Eur., BP, 100-110%, 51.0-59.0% Al2(SO4)3

纳米二氧化锡  99.9% metals basis，50-70nm  硫酸铝 99.99% metals basis

AMBERLITE IRA402 CL阴离子交换树脂 氯型  赫斯特荧光燃料，33258 98%

橡胶PTFE垫片,配套120ZSS棕色瓶,φ20mm*1.4mm  赫斯特荧光燃料，33342 98%

中空纯四氟塞,配套12?

(R)-4-Carboxyphenylglycine10mg 50mg>98.00%Cas No. 134052-68-9C9H9NO4

(S)-Willardiine ((-)-Willardiine)10mg 50mg>98.00%Cas No. 21416-43-3C7H9N3O4

(S)-SNAP 511410mg 50mg>98.00%Cas No. 157604-55-2C30H35NO6

(S)-CPW 39910mg 50mg>98.00%Cas No. 389888-02-2C10H13N3O4

(S)-(-)-HA-96610mg 50mg>98.00%Cas No. 111821-58-0C4H8N2O2

(S)-(-)-Bay K 864410mg 50mg>98.00%Cas No. 98625-26-4C16H15F3N2O4

(S)-(-)-5-Iodowillardiine10mg 50mg>98.00%Cas No. 140187-25-3C7H8IN3O4