性能参数

产品名称

Necrostatin 2

规格

5mg 10mg 25mg 50mg

货号

GOY-Y2889

 含量

>98.00%

CAS

852391-19-6

别名

MTH-DL-Tryptophan, Necroptotic Inhibitor

化学名

(5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione

分子式

C13H12ClN3O2

分子量

分子量 277.71

溶解度

DMF: 20 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.50 mg/ml,DMSO: 14 mg/ml,Ethanol: 3 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor.

Evaluation of necroptosis inhibitory activity is performed using a FADD-deficient variant of human Jurkat T cells treated with TNF-α. Utilizing these conditions the cells efficiently undergo necroptosis, which is completely and selectively inhibited by Necrostatin 2 (EC50=50 nM). Necrostatin 2 shows activity in a broad range of necroptosis cellular systems[1]. Necrostatin 2 at 30 μM completely protects L929 cells from TNF-α-induced necroptosis. In addition to TNF-α, the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD.fmk) has also been found to induce necrosis in L929 cells, which is efficiently inhibited by Necrostatin 2[2]. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM[3].

三乙胺 CP,98.0%  1,4 -双(二苯基膦)丁烷(1,5环辛二烯)铑(I)四氟 98%

三乙胺 for HPLC, ≥99.5% (GC)  双(1,5-环辛二烯)-三氟甲磺酸铑 98%

三乙胺 GR,99.5%  二氯化二铑(双降冰片二烯) 铑 96%

三乙胺 用于氨基酸分析, ≥99.5% (GC)  三氟甲烷磺酸铜(Ⅱ) 98%

三乙胺 LC-MS淋洗剂, ≥99.5% (GC)  二环己基氯化膦 97%

(R)-(-)-3-氯-1,2-丙二醇 97%  1,4,7,10-四氮杂环十二烷 9?

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