性能参数

产品名称

Nutlin-3a chiral

规格

0mM (in 1mL DMSO) 10mg 50mg 200mg

货号

GOY-Y2895

 含量

>98.00%

CAS

675576-98-4

别名

Nutlin-3a;Nutlin 3a

化学名

4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

分子式

C30H30Cl2N4O4

分子量

分子量 581.49

溶解度

≥ 29.0745 mg/mL in DMSO, ≥ 104.4 mg/mL in EtOH

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Nutlin-3 is a small-molecule inhibitor of MDM2 (mouse double minute 2) with IC50 value of 0.09μM [1].

Nutlin-3 binds MDM2 in the TP53-bindingpocket, thereby interfering with MDM2-directed TP53 degradation. This has been shown to cause cell cycle arrest, growth inhibitionand apoptosis in both solid tumors and lymphoid neoplasms.In mantle cell lymphoma(MCL), it is reported that Nutlin-3 can inhibit cell growth and activate apoptosis in bothwt-TP53(IC50 of 1 to 10μM) and mt-TP53(IC50 of 22.5μM) cells [2].

Nutlin-3 can also effectcell cycle in gastric cancer cell lines. It induces G1 arrest inMKN-45 and SNU-1 cell lines. In vitro assay shows Nutlin-3can enhance the antitumoreffects of conventional chemotherapeutic agents in several gastric cancer cell lines. And in in vivo assay, Nutlin-3 significantly inhibits the growth of xenograft tumors [3].

镍 AR,99.5%  2-二环己膦基-2'-(N,N-二甲胺)-联苯  98%

不锈钢粉 200目  二叔丁基氯化膦 96%

不锈钢粉 200目  二溴双(三苯基磷)化镍 99%

不锈钢粉 200目  (S, S)-环己二胺 98%

敌草隆 分析标准品，99.5%  (R, R)-环己二胺 98%

敌草隆 99%  2-(二苯基膦基)苯甲酸 97%

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