性能参数

产品名称

Raltitrexed

规格

10mM (in 1mL DMSO) 10mg 50mg 100mg

货号

GOY-Y2921

 含量

>98.00%

CAS

112887-68-0

别名

N/A

化学名

(2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid

分子式

C21H22N4O6S

分子量

分子量 458.49

溶解度

≥ 154mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Raltitrexed is an inhibitor of thymidylate synthase (Ki = 62 nM).[1] It inhibits the growth of L1210 mouse lymphocytic leukemia cells in vitro (IC50 = 8 nM) as well as reduces thymidylate synthase activity and completely eliminates tumors in a mouse L1210:ICR ascitic tumor model when administered at a dose of 4 mg/kg, effects that can be reversed by administration of thymidine. It also reduces tumor growth and the number of metastases in an HCT116-luc mouse xenograft model.[2] Formulations containing raltitrexed have been used in the treatment of advanced colorectal cancers.

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