性能参数

产品名称

SMIP004

规格

5mg 10mg 25mg 50mg

货号

GOY-Y2943

 含量

>98.00%

CAS

143360-00-3

别名

SMIP 004;SMIP-004

化学名

N-(4-butyl-2-methylphenyl)acetamide

分子式

C13H19NO

分子量

分子量 205.3

溶解度

≥ 20.5 mg/mL in DMSO, ≥ 53.6 mg/mL in EtOH with ultrasonic

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

IC50 Value: 1.09 uM (MTT assay in LNCaP-S14 cells) [1] SMIP004 (N-(4-butyl-2-methyl-phenyl) acetamide) is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells. Unlike SMIP001, SMIP004 was found to downregulate SKP2 and to stabilize p27, although neither SMIP is a proteasome inhibitor. in vitro: Whereas SMIP012 and 016 were moderately toxic in normal fibroblasts, SMIPs 001 and 004 showed substantial cancer cell specificity being at least five times more potent in LNCaP-S14 than in IMR90 cells , treatment with either MG132 or SMIP004 increased p27 half-life to > 6 h [1]. Both SMIP001 and 004 led to a strong increase in the recruitment of p27 to CDK2, while SMIP001 also slightly increased coprecipitation of p21 (Figure 6c). SMIP004 also reduced the amounts of cyclins E and A retrieved with CDK2. This was paralleled by a marked downregulation of cyclins E and A upon SMIP004 treatment. SMIP004 decreased the levels of positive cell cycle regulators, upregulated cyclin-dependent kinase inhibitors, and resulted in G1 arrest, inhibition of colony formation in soft agar, and cell death [2]. in vivo: SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in mice [2]. Clinical trial: N/A

卟啉类显色剂 显色剂  **基氧基苯基硅烷 85%

孟加拉玫瑰红 BR  苯基三乙氧基硅烷 98%

苏丹红Ⅲ CP  7-氯喹哪啶 99%

氯磺酚S 显色剂，96.0%  5-甲基吲哚 99%

苏丹I  Dye content 98%  2-氨基噻唑 97%

三溴偶氮胂 显色剂  3-溴-5-氯水杨醛 98%

Aniracetam10mM (in 1mL DMSO) 50mg 100mg 250mg>98.00%Cas No. 72432-10-1C12H13NO3

ATP synthase inhibitor 15mg 10mg 50mg 100mg>98.00%Cas No. 1023043-30-2C17H18ClN3O3S2

ASP25355mg 10mg 50mg 100mg>98.00%Cas No. 374886-51-8C22H18N6O

Azimilide Dihydrochloride5mg 10mg 50mg 100mg>98.00%Cas No. 149888-94-8C23H30Cl3N5O3

Azimilide10mM (in 1mL DMSO) 5mg 10mg 50mg>98.00%Cas No. 149908-53-2C23H28ClN5O3

AZD-62801mg 5mg 10mg 20mg>98.00%Cas No. 942436-93-3C20H22N4O3

Bevantolol hydrochloride10mM*1 mL in DMSO 25mg 50mg 100mg>98.00%Cas No. 42864-78-8C20H28ClNO4