性能参数

产品名称

SLF

规格

5 mg 10 mg 50 mg 100 mg

货号

GOY-Y2945

 含量

>98.00%

CAS

195513-96-3

别名

N/A

化学名

N/A

分子式

C30H40N2O6

分子量

分子量 524.7

溶解度

DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2)(1:3): .2 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation. Synthetic ligand of FKBP (SLF) is a cell-permeable analog of FK-506 that binds tightly to FKBP but lacks the ability to inhibit calcineurin. By itself, SLF does not exhibit a significant cellular response. However, homodimers of SLF or heterodimers with another protein ligand, provide a method to promote the dimerization of ligand-specific fusion proteins to induce signaling events within a cellular environment. For example, SLF monomers connected with a 10-atom linker activates Fas signaling via Fas-FKBP fusion proteins with an EC50 of 6 nM.

氧化钙 99.99% metals basis  乙基麦芽酚 99%

氢氧化钙  ACS, ≥95.0%  乙基麦芽酚 99%, FCC, FG

2,6-二叔丁基对甲酚 CP,98%  麦芽酚 99%

乙烯利  >90.0%(HPLC)  麦芽酚 99%,FCC,FG

石墨 CP,99.85%  麦芽酚 ≥98.5%,natural, FG

水合联氨  AR,80%溶液  150办公桌 1400*750*730，钢制

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Capsiconiate1mg 5mg 10mg 25mg>98.00%Cas No. 946572-73-2C20H

CARIPORIDE10mM (in 1mL DMSO) 10mg 50mg 100mg>98.00%Cas No. 159138-80-4C12H17N3O3S

CAY107191mg 5mg 10mg 25mg>98.00%Cas No. 1942919-63-2C25H20Cl2N2O2

CAY106081mg 5mg 10mg 25mg>98.00%Cas No. 457897-92-6C18H22Cl2N2O4S