性能参数

产品名称

Taltobulin (HTI-286)

规格

10mM*1mLinDMSO 5mg 10mg 50mg

货号

GOY-Y2953

 含量

>98.00%

CAS

228266-40-8

别名

N/A

化学名

N/A

分子式

C27H43N3O4

分子量

分子量 473.65

溶解度

DMSO : ≥ 100 mg/mL (211.13 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.IC50 value:Target: tubulinin vitro: HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 was a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2].in vivo: Intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibited growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy was superior to sequential treatment in the LNCaP model [2].

[1]. Vashist YK, et al. Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin. World J Gastroenterol. 2006 Nov 14;12(42):6771-8. [2]. Hadaschik BA, et al. Targeting prostate cancer with HTI-286, a synthetic analog of the marine sponge product hemiasterlin. Int J Cancer. 2008 May 15;122(10):2368-76.

过氧化氢溶液 ACS,not stabilized,30% (RT)  环戊乙酸 97%

过氧化氢溶液(35%) h. Eur., BP, USP, 30-31%   内消旋-2,3-二巯基丁二酸 98%

硝酸 CP  硫代苹果酸 98%

硝酸 GR  N-（3-溴丙基）邻苯二甲酰亚胺 98%

磷酸 AR, ≥85 wt. % in H2O  吡哆胺二盐酸盐 98%

磷酸  for HPLC, 85-90%  硫脲 AR，99%

GSK-5498A10mM*1mLinDMSO 2mg 5mg 10mg>98.00%Cas No. 1253186-49-0C18H11F6N3O

GS9675mg 10mg 50mg 100mg>98.00%Cas No. 1262618-39

GV-196771A1mg 5mg 10mg 20mg>98.00%Cas No. 166974-23-8C20H13Cl2N2NaO3

GTS 21 dihydrochloride5mg 10mg 50mg 100mg>98.00%Cas No. 156223-05-1C19H20N2O2.2HCl

H3B-1205mg 10mg 50mg 100mg>98.00%Cas No. 2194903-42-7C19H24N4O2S

Hypophyllanthin1mg 5mg 10mg 25mg>98.00%Cas No. 33676-00-5C24H30O7