性能参数

产品名称

Tipiracil

规格

5mg 10mg 50mg 100mg

货号

GOY-Y2959

 含量

>98.00%

CAS

183204-74-2

别名

N/A

化学名

N/A

分子式

C9H11ClN4O2

分子量

分子量 242.66

溶解度

H2O: 1 mg/mL (4.12 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Tipiracil is a thymidine phosphorylase (TPase) inhibitor. thymidine phosphorylase[1]

Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. The combination of Trifluridine and Tipiracil is a new oral treatment for metastatic colorectal cancer[2]. Tipiracil prevents degradation of FTD through a first-pass effect as a thymidine phosphorylase inhibitor[3].

[1]. Lee SJ, et al. Thymidine phosphorylase influences [(18)F]fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1327-35. [2]. Raedler LA. Lonsurf (Trifluridine plus Tipiracil): A New Oral Treatment Approved for Patients with Metastatic Colorectal Cancer. Am Health Drug Benefits. 2016 Mar;9(Spec Feature):97-100. [3]. Tanaka N, et al. Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models. Oncol Rep. 2014 Dec;32(6):2319-26.

正己烷 Standard for GC,>99.5%(GC)  氯甲基苯硫醚 95%

正己烷  >99%(GC)  3-氯茴香硫醚 97%

正己烷 光谱纯, ≥98.0% (GC)  3-甲基-5-氯苯并噻吩 97%

正己烷 ACS,>98.5%(GC)  3,5-二氯苯硫酚 97%

甲醇 无丙酮，用于Romanowsky甲醇染色法  2,4-二甲基苯硫酚 95%

甲醇  梯度色谱级, ≥99.9%  2,5-二甲基苯硫酚 98%

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