性能参数

产品名称

Trametinib 

规格

0mM (in 1mL DMSO) 50mg 200mg 500mg

货号

GOY-Y2962

 含量

>98.00%

CAS

871700-17-3

别名

Trametinib, GSK-1120212, GSK1120212, Mekinist, JTP74057, JTP-74057

化学名

N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide

分子式

C26H23FIN5O4

分子量

分子量 615.39

溶解度

≥ 15.38mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase. It has demonstrated broad antitumor activities in a variety of tumor xgenograft models, including HT-29 and COLO205 colorectal tumor cell lines. Trametinib induces expression of p15 and p27, reduces cyclin D1 levels, and causes dephosphorylation of RB protein and G1-phase arrest with a reduction of TS expression in HT-29 cells. It also effectively inhibits p-ERK 1/2 resulting in cell growth inhibition in tumor cell lines harboring B-RAF mutant.

无水乙醚 GR,99%  劳森试剂 97%

乙醚 for HPLC, >99.0%(GC)，含2%乙醇作稳定剂  3-羟基苯硫酚 96%

  >99.0% (GC)  苯硫基乙酸甲酯 97%

OP-4乳化剂 亲油，羟值150±10  4-甲氧基茴香硫醚 98%

O113278-500ml  OP-10乳化剂  2-羟基茴香硫醚 98%

焦亚硫酸钾 AR，95.0%  4-甲硫基苯乙酮 97%

PD01760781mg 5mg 10mg 20mg>98.00%Cas No. 248922-46-5C23H30F2N2O

(E/Z)-Sivopixant5 mg 10 mg 25 mg 50 mg 100 mg>98.00%Cas No. 1640808-39-4C25H22ClN5O5

(Rac)-NMDAR antagonist 15mg 10mg 25mg 50mg 100mg>98.00%Cas No. 2435557-99-4C20H20BrN3O2

(R)-Posenacaftor sodium5 mg 10 mg 25 mg 50 mg 100 mg>98.00%Cas No. 2095064-09-6C27H26NNaO5

(R)-Lanicemine5 mg 10 mg 25 mg 50 mg 100 mg>98.00%Cas No. 190581-71-6C13H14N2