性能参数

产品名称

Voreloxin

规格

10mM (in 1mL DMSO) 5mg 10mg 25mg

货号

GOY-Y2972

 含量

>98.00%

CAS

175414-77-4

别名

SNS-595; Vosaroxin; AG 7352

化学名

7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic acid

分子式

C18H19N5O4S

分子量

分子量 401.44

溶解度

<4.01 mg/mL in DMSO, <2.51 mg/mL in EtOH, <2.49 mg/mL in H2O

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Voreloxin, formerly known as SNS-595 or AG-7352, is a novel naphthyridine analog, which is structurally related to the quinolone antibiotics, a chemical class not previously used for the treatment

of cancer.

In vitro: In vitro studies demonstrated voreloxin has broad anti-proliferative activity in 11 tumor cell lines, with IC50 values ranging from 0.04 to 0.97 μM. Similar activity was observed in vitro in drug-resistant cell lines, including those that overexpress P-glycoprotein [2].

In vivo: After a single intravenous dose, voreloxin concentrations in tumor were correlated with induction of the apoptosis marker caspase-3. Administration of voreloxin at 20 mg/kg weekly inhibited tumor growth (86%). Voreloxin demonstrated strong dose-dependent tumor growth inhibition (63–88%) in 10 of 11 solid tumor xenograft models [2].

Clinical trial: Voreloxin showed an acceptable safety profile with clinical activity in patients with relapsed/refractory solid tumors. The maxmum tolerence dose was schedule-dependent. Voreloxin is now in clinical studies of ovarian cancer and acute myeloid leukemia [3].

L-丙氨酰-L-谷胺酰胺 98%  10X分子筛 干燥剂用

4-联苯硼酸  98%  蒽 98%

3-溴邻二甲苯 98%  氧化钕 99%

2-甲酸吡啶铬(III) 98%  碳化钨 粉末，99.9% metals basis, <10μm

2,3-环戊烯并吡啶 98%  天青Ⅱ AR

D-环丝氨酸 98%  火棉胶 AR,4-8% in ethanol/diethyl ether

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