性能参数

产品名称

Z-VEID-FMK

规格

1mg 5mg 10mg 25mg

货号

GOY-Y2984

 含量

>98.00%

CAS

Cas No.

别名

Caspase-6 inhibitor (fluoromethylketone),Benzyloxycarbonyl-Val-Glu(OMe)-Ile-?Asp(OMe)-fluoromethylketone

化学名

methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate

分子式

C31H45FN4O10

分子量

分子量 652.71

溶解度

≥ 113.4mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

When compared to other caspase inhibitors, Z-DRHD-FMK inhibited caspase 6 activity more effectively than the general caspase inhibitor Z-Val-Ala-Asp (OMe)-fluoromethy ketone (Z-VAD-FMK) or the caspase 6 inhibitor Z-Val-Glu(Ome)-Ile-Asp(OMe)-fluoromethyl ketone (Z-VEID-FMK). However, it was less effective in inhibiting TNFα-induced apoptosis than Z-VAD-FMK or Z-VEID-FMK, presumably because caspase 6 is only one of at least three effector caspases, the others being caspase 3 and 7, that are active during caspase dependent apoptosis. Loss of DNA-binding activity and TNFα-induced apoptosis can be prevented by caspase-6-preferred inhibitor (Z-VEID-FMK)1.

The caspase-6-specific inhibitor Z-VEID- FMK and general caspase inhibitors significantly prevent apoptosis of caspase-6-microinjected neurons2.

Z-VEID-FMK, which inhibits caspase-6, was also able to abolish the cleavage of procaspase-8, although caspase-6 is activated downstream of caspase-8 in Fas-mediated apoptosis3.

乙酸苯汞 分析标准品（剧毒品）  氟化铝 99.9% metals basis

2,4,6-三(二甲氨基甲基)苯酚 95%  氟铝酸铵  98%

三叔丁氧基氢化铝锂 97%  乙酸钴，四水 99.9% metals basis

硼氢化锂 95%  硫酸钴，七水 AR，99.5%

硼氢化锂 2.0M四氢呋喃溶液  硫酸钴，七水 99.99% metals basis

三仲丁基硼氢化锂 1M THF溶液  碱式碳酸镍 AR

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