性能参数

产品名称

Z-VDVAD-FMK

规格

1mg 5mg 10mg 25mg

货号

GOY-Y2985

 含量

>98.00%

CAS

210344-92-6

别名

Z-VDVAD-fluoromethylketone, Caspase-2 Inhibitor (fluoromethylketone),Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK

化学名

methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-2-[[(2S)-4-methoxy-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxopentanoate

分子式

C32H46N5O11F

分子量

分子量 695.73

溶解度

≥ 34.8mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Jurkat T-lymphocytes treated with an irreversible caspase-2 inhibitor, benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethyl ketone (Z-VDVAD-FMK), or stably transfected with pro-caspase-2 antisense (Casp-2/AS) are refractory to cytochrome c release stimulated by etoposide1.

When etoposide-induced activation of pro-caspase-2 is subverted by Z-VDVAD-FMK or stable transfection of pro-caspase-2 antisense, cytochrome c release and other manifestations of apoptosis are attenuated.

OxyHb significantly activated both caspase-2 and caspase-3 in bovine brain microvessel endothelial cells. The irreversible caspase inhibitors Z-VDVAD-FMK (caspse-2 inhibitor) and Z-DEVD-FMK (caspase-3 inhibitor) significantly reduced cell detachment, caspase-2 and -3 activities, DNA ladders, and proteolytic cleavage of PARP2. Activation of caspase-2 and caspase-3 is essential for OxyHb induced apoptosis in endothelial cells, and Z-VDVAD-FMK and Z-DEVD-FMK have the potential to protect cells.

The minimal-length inhibitor of caspase-2, Z-VDVAD-fmk, which also inhibits caspases 3 and 73, prevented doxorubicin-induced nuclear apoptosis, but not cell death4.

三叔丁氧基氢化铝锂 1.0 M in THF  邻苯二甲酰亚胺 99%

绿原酸 95%  1,3,5-**苯 CP,97%

羟基柠檬酸钾 95%  1,2,4-**苯 98%

穿心莲内酯  98%  氢氧化钾 电子级, 99.99% metals basis，钠除外

穿心莲内酯  分析标准品  氢氧化钾 电子级，99.999% metals basis，钠除外

盐酸小檗碱 98%  氢氧化钠 Ph. Eur., BP, NF, E524, 98-100.5%, pellets

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Fura-2 (potassium salt)500μg 1mg 5mg>95.00%Cas No. 113694-64-7C29H22N3O14?5K

Mivacurium (chloride)1mg 5mg 10mg>95.00%Cas No. 106861-44-3C58H80N2O14?2Cl

Oligomycin Complex1mg 5mg 10mg>95.00%Cas No. 1404-19-9C135H220O33

Pancuronium (bromide hydrate)5 mg 10 mg 25 mg>95.00%Cas No. N/AC35H60N2O4.2Br [XH2O]

(±)5(6)-DiHET25μg 50μg 100μg 250μg>95.00%Cas No. 213382-49-1C20H34O4