性能参数

产品名称

MIR96-IN-1

规格

1mg 5mg 10mg 50mg 100mg

货号

GOY-Y2993

 含量

>98.00%

CAS

1311982-88-3

别名

N/A

化学名

N/A

分子式

C33H48N8O2

分子量

分子量 588.79

溶解度

DMSO : ≥ 100 mg/mL (169.84 mM);H2O : < 0.1 mg/mL (insoluble)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.Target: microRNA-96in vitro: MIR96-IN-1 inhibits biogenesis of its target precursor miRNA to varying extents : MIR96-IN-1 reduces the expression level of miR-96 by 90% at 40 μM. MIR96-IN-1 efficiently and selectively silences production of miR-96 at 40 μM while not affecting miR-182 or -183. Moreover, MIR96-IN-1 inhibits Drosha cleavage of pri-miR-96, as evidenced by an increase in the levels of pri-miR-96 and a reduction in levels of pre- and mature miR-96 in treated cells, as expected if MIR96-IN-1 binds to the Drosha site. [1]

[1]. Velagapudi SP, et al. Sequence-based design of bioactive small molecules that target precursor microRNAs. Nat Chem Biol. 2014 Apr;10(4):291-7. [2]. Haga CL, et al. Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling. ACS Chem Biol. 2015 Oct 16;10(10):2267-76. [3]. Velagapudi SP, et al. Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis. J Am Chem Soc. 2011 Jul 6;133(26):10111-8.

硫酸铝钾 AR，99.5%  锑粒 99.9999% metals basis

L-抗坏血酸棕榈酸酯 99%  纳米氮化铝 99.9% metals basis,50nm

L-抗坏血酸棕榈酸酯 USP级  氮化铝 N >33.0%， D50/2.0 μm

秋水仙碱 98%  氮化铝 N >32.5 % ，D97/5.0 μm

植物血球凝集素 50-100 ug/ml  硫化锑 98%

4-氟苯乙烯 97%  氟化铝 99%

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