性能参数

产品名称

Necrostatin-34

规格

5 mg 10 mg 25 mg 50 mg 100 mg

货号

GOY-Y2999

 含量

>98.00%

CAS

375835-43-1

别名

N/A

化学名

N/A

分子式

C18H16N4O2S2

分子量

分子量 384.48

溶解度

DMSO : 125 mg/mL (325.11 mM; Need ultrasonic)

储存条件

4°C, protect from light

General tips

用途

仅供科研

价格

电询

详细内容

Necrostatin-34 (Nec-34), a RIPK1 kinase inhibitor, stabilizes RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain[1].

Necrostatin-34 (Nec-34) exhibits IC50 values of 667 nM and 134 nM for TNFα in FADD def-Jurkat cells and L939 cells, respectively[1].Necrostatin-34 (Nec-34, 10 μM) inhibits the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation[1].Necrostatin-34 (Nec-34) may block TNFα-induced complex II formation by inhibiting the activation of RIPK1 kinase[1].

[1]. Huyan Meng, et al. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell Discov. 2021 Jun 1;7(1):41.

.

间甲酚 CP  硫化镉 99.999%

邻苯二酚 AR,99.0%  氯化铈，无水 99.9% (REO)

邻苯二酚 CP,98.0%  铜粒 99.99% metals basis,粒径<5mm

邻苯二酚 standard for GC, ≥99.5% (GC)  铜粉  99.8% metals basis，20μm

2,6-二甲基苯酚 99%  硝酸铯 99.99%

2,6-二甲基苯酚 分析标准品  硝酸铯 AR,99.0%

Purity:

Nilvadipine-d41 mg 5 mg>99.00%Cas No. N/AC19H15D4N3O6

AICA Ribonucleotide1 mg 5 mg 10 mg>95.00%Cas No. 3031-94-5C9H15N4O8P

Myr-ZIP1 mg 5 mg 10 mg>95.00%Cas No. N/AC90H154N30O17·XCF3COOH

Endostatin (84-114)-NH2 (JKC367)1mg 5mg 10mg 25mg0.9966Cas No. N/AC161H236N48O43

膜转运蛋白/离子通道

PF 477857410mg>98.00%Cas No. 1219633-99-4C19H22N2O3S2