性能参数

产品名称

Panobinostat (LBH589)

规格

10mM (in 1mL DMSO) 10mg 50mg 200mg 500mg

货号

GOY-Y3008

 含量

>98.00%

CAS

404950-80-7

别名

Panobinostat,LBH589,LBH-589, Faridak, NVP-LBH589,

化学名

(E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide

分子式

C21H23N3O2

分子量

分子量 349.43

溶解度

≥ 17.47mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Panobinostat, as known as LBH589, is a novel and potent hydroxamic acid-based deacetylase inhibitor (DACis)that inhibits a broad spectrum of histone deacetylases (HDACs), including all Classes 1, 2 and 4 HDAC enzymes, at low nanomolar concentrations. According to previous studies, it not only induces apoptosis in multiple myeloma (MM) cells via caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage, but also induces potent cell growth inhibition, cell-cycle arrest, and apoptosis in a time- and dose-dependent manner in both Philadelphia chromosome-negative (Ph-) actue lymphoblastic leukemia (ALL) cells lines (T-cell MOLT-4 and pre-B-cell Reh), which are correlated with induction of histone (H3K9 and H4K8) hyperacetylation, activation of p21 and p27, and suppression of c-Myc.

苯甲酸甲酯 分析标准品，>99.5% (GC)  钙 99.5% metals basis

苯甲酸甲酯 99%  钙 99.98% metals basis

左肉碱 98%  硫化铜 99.99%

甲砜霉素  99.5%  氟化铯 99.99% metals basis

甲砜霉素  分析标准品，99.9%  草酸铈 98%

乙腈 standard for GC, ≥99.9%  草酸铈 99.9% metals basis

Phaclofen50mg 10mg>98.00%Cas No. 114012-12-3C9H13ClNO3P

PPDA10mg 50mg>98.00%Cas No. 684283-16-7C21H18N2O5

Pozanicline1mg 5mg>98.00%Cas No. 161417-03-4C11H16N2O

PNU 37883 hydrochloride10mg 50mg>98.00%Cas No. 57568-80-6C21H35N3O.HCl

PMPA (NMDA antagonist)10mg 50mg>98.00%Cas No. 113919-36-1C6H13N2O5P

PK-THPP10 mg 50 mg>98.00%Cas No. 1332454-07-5C29H32N4O2

Piperine10mM (in 1mL DMSO) 100mg>98.00%Cas No. 94-62-2C17H19NO3