性能参数

产品名称

Palomid 529

规格

5mg 10mg 50mg 500mg 1g

货号

GOY-Y3009

 含量

>98.00%

CAS

914913-88-5

别名

N/A

化学名

8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]benzo[c]chromen-6-one

分子式

C24H22O6

分子量

分子量 406.43

溶解度

≥ 41mg/mL in DMSO with gentle warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Palomid 529 (P529) is a novel potent antitumour PI3K/Akt/mTOR inhibitor with a GI50 of <35 μM in the NCI-60 cell lines panel.[1] Palomid 529 inhibits both VEGF-driven and bFGF-driven endothelial cell proliferation with IC50 of 20 nM and 30 nM, respectively.

PI3K activates AKT,then AKT activate CREB,inhibit p27locate FOXO in the cytoplasm, activate PtdIns-3ps, and mTOR which can effect transcription of p70 or 4EBP1.[2,3]

In many cancers, this pathway is overactive, thus reducing apoptosis and allowing proliferation. This pathway is necessary, however, to promote growth and proliferation over differentiation of stem cells, neural stem cells specifically. Additionally, this pathway has been found to a be a necessary component in neural long term potentiation.[4]Lowering the effect of the PI3K pathway and increasing the effect of GSK3β and HB9 in NSCs is a potential way of generating these cells better for survival of the neurons. Amplifying the PI3K/AKT pathway increases this neural outgrowth which can determine appropriate treatment concentrations of bisperoxovanadium to stimulate axonal outgrowth but not cause cancer.Not only Palomid 529 inhibits radiation-induced overexpression of Id-1 and VEGF, but also down-regulates radiation-induced MMP-2 and MMP-9. [5]

乙腈 for HPLC, ≥99.9%  氧化铜 99.9% metals basis，10μm

乙腈 农残级, ≥99.9%(GC)  碲化镉 99.999%，5N

乙腈 >99.5%(GC)  碲化镉 99.9999%，6N

乙腈 AR,99.0%  六价铬标准溶液 六价铬标准溶液 1000μg/ml

乙腈 光谱纯, ≥99.8%  碘化铯 分析标准品，用于高通量质谱,99.9995%

乙腈 for DNA synthesis, ≥99.9% (GC)  硫酸铯 99.99% metals basis

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Proparacaine HCl10mM (in 1mL DMSO) 50mg>98.00%Cas No. 5875-06-9C16H26N2O3.HCl

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