性能参数

产品名称

PDK4-IN-1 hydrochloride

规格

10mM*1mL in DMSO 5mg 10mg 50mg 100mg

货号

GOY-Y3010

 含量

>98.00%

CAS

2310262-11-2

别名

N/A

化学名

N/A

分子式

C22H20ClN3O2

分子量

分子量 393.87

溶解度

DMSO: 125 mg/mL (317.36 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 hydrochloride potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 hydrochloride has antidiabetic, anticancer and anti-allergic activity[1].

[1]. Lee D, et al. Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases. J Med Chem. 2019 Jan 24;62(2):575-588.

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