性能参数

产品名称

Phenoxodiol

规格

1mg 5mg 10mg 50mg 100mg

货号

GOY-Y3016

 含量

>98.00%

CAS

81267-65-4

别名

N/A

化学名

N/A

分子式

C15H12O3

分子量

分子量 240.25

溶解度

DMSO: ≥ 100 mg/mL (416.23 mM); H2O: < 0.1 mg/mL (insoluble)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Phenoxodiol, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2]. Caspase, DNA topoisomerase II[1][2].

[1]. Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22(17):2611-20. [2]. Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14(1):110.

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