性能参数

产品名称

Pifithrin-α (PFTα)

规格

0mM (in 1mL DMSO) 5mg 10mg 25mg 50mg

货号

GOY-Y3019

 含量

>98.00%

CAS

63208-82-2

别名

N/A

化学名

2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone;hydrobromide

分子式

C16H18N2OS.HBr

分子量

分子量 367.3

溶解度

≥ 17.45 mg/mL in DMSO, ≥ 7.12 mg/mL in EtOH with ultrasonic and warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Pifithrin-α is a synthetic, water-soluble and stable inhibitor of p53 [1].

Pifithrin-α is firstly found to block the activation of p53-responsive lacZ in ConA cells and reduce activation of endogenous cellular p53-responsive genes. In MEF cells transformed with E1a+ras, 10μM Pifithrin-α can inhibit the apoptosis of the cells and this anti-apoptotic activity is p53-dependent. Pifithrin-α also inhibits the growth arrest of human diploid fibroblasts induced by DNA damage but has no effect on p53-deficient fibroblasts. In addition, Pifithrin-α induces G2-arrest of cells after gamma irradiation [1].

Moerover, Pifithrin-α can also induce cell cycle arrest and growth arrest of embryonic stem cells. Treatment of Pifithrin-α significantly downregulates the protein lever of Nanog (a pluripotency marker).It is proved that the inhibition of p53 activity caused by Pifithrin-α has no effect on ES cell viability [2].

2,3-萘二甲醛 99%  氟化钬(III) 无水,粉末, 99.99% metals basis

TNTU 98%  溴化钬(III) 无水,粉末, 99.99% metals basis

乳清酸一水合物 98%  碘化钬(III) 99.99% REO

S-(1-氧代-2-吡啶基)-N,N,N′,N′-四甲基硫脲四氟硼酸盐  98%  硫酸钬(III),八水 99.9%

硫代乙酸钾 98%  磷酸钬(III) 粉末

8-喹啉磺酰氯 98%  铟 99.99%,granular

TCN 21310mg 50mg>98.00%Cas No. 556803-08-8C18H24N4OS2

TC-P 26210mg 50mg>98.00%Cas No. 873398-67-5C14H18N4

TC-I 200010mg 50mg>98.00%Cas No. 1159996-20-9C23H18F4N2O

TC AQP1 110 mg 50 mg>98.00%Cas No. 37710-81-9C12H10O4

TB 2100710mg 50mg>98.00%Cas No. 207306-50-1C15H17NO2S3

THIP1mg 5mg>98.00%Cas No. 64603-91-4C6H8N2O2